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Article

Preventing and treating neurotrophic keratopathy by a single intrastromal injection of AAV-mediated gene therapy

1 Oct 2024

Abstract excerpt

PURPOSE: Neurotrophic keratopathy (NK) is a degenerative corneal condition resulting from corneal nerve injury. Current therapies, including the recombinant human nerve growth factor (rhNGF) therapy, requires continuous administration. This study aims to develop a novel and highly effective gene therapy strategy for the prevention and treatment of NK. METHODS: Adeno-associated virus (AAV) was transduced into...

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PMID: 39362525
DOI: 10.1016/j.jtos.2024.09.010

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