Article

AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice

2022-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not eliminate latent HSV, and thus is only suppressive rather than curative. We developed a potentially curative approach to latent HSV infection and pathogenesis, base...

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Identifiers and source

Literature Corpus work: 552394f9-0fdb-5302-b4fd-5c843578cdc7
DOI: 10.1101/2022.09.23.509057

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