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Article

A Nerve-Dependent NGF Receptor Switch Controls Corneal Epithelial Renewal In Neurotrophic Keratopathy

2026-07-01

Abstract excerpt

Corneal epithelial integrity depends on continuous epithelial renewal by limbal epithelial stem cells (LESCs), a process tightly linked to sensory innervation. Loss or impairment of innervation causes neurotrophic keratopathy (NK), a sight-threatening degenerative disease for which rhNGF, the only FDA-approved pharmacologic therapy, often has limited efficacy in advanced or refractory disease. The mechanistic basi...

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Literature Corpus work
485529d6-c374-5971-8c42-d5142e0c16ac
DOI
10.64898/2026.06.30.735622
Open publication

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A Nerve-Dependent NGF Receptor Switch Controls Corneal Epithelial Renewal In Neurotrophic KeratopathyDOI 10.64898/2026.06.30.735622
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