Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice

11 Jan 2021

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness. Current treatments for HSV-1 do not eliminate the virus from the site of infection or latent reservoirs in the trigeminal ganglia. Here, we target HSV-1 genomes directly using mRNA-carrying lentiviral particles that simultaneously deliver SpCas9 mRNA and viral-gene-targeting guide RNAs (designated HSV-1-erasing lentiviral particles,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to Ocular Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33432198
DOI: 10.1038/s41587-020-00781-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in micePMID 33432198Read ↗

Intracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitisSemantic proximity Read ↗

Single AAV-Mediated CRISPR-SaCas9 Inhibits HSV-1 Replication by Editing ICP4 in Trigeminal Ganglion NeuronsSemantic proximity Read ↗

In vivo CRISPR gene editing in patients with herpetic stromal keratitisSemantic proximity Read ↗

CRISPR/Cas9, a powerful tool to target human herpesvirusesSemantic proximity Read ↗

In Vivo CRISPR Gene Editing in Patients with Herpes Stromal KeratitisSemantic proximity Read ↗

Gene editing and elimination of latent herpes simplex virus in vivoSemantic proximity Read ↗

CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation.Semantic proximity Read ↗

Clinical management of herpes simplex virus infections: past, present, and futureSemantic proximity Read ↗

Potential Application of the CRISPR/Cas9 System against Herpesvirus InfectionsSemantic proximity Read ↗

Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX SystemsSemantic proximity Read ↗

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent InfectionsSemantic proximity Read ↗

Suppression of HSV-1 infection and viral reactivation by CRISPR-Cas9 gene editing in 2D and 3D culture modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.