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Article

A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection

3 Oct 2024

Abstract excerpt

Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeting C. difficile toxins and virulence factors. This multivalent vaccine elicited robust and long-lived systemic and mucosal antigen-specific humoral and cellular immune responses across animal models, independent of...

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PMID: 39361752
DOI: 10.1126/science.adn4955

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