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Article

An mRNA vaccine encoding five conserved Group A Streptococcus antigens

1 Jul 2025

Abstract excerpt

A commercial vaccine to address the high global burden of Group A Streptococcus (GAS) disease is an urgent and unmet medical need. Messenger RNA (mRNA) lipid-nanoparticle (LNP) vaccines represent a largely untapped platform for targeting bacterial pathogens. Here, we evaluate the immunogenicity and preclinical efficacy of a multicomponent mRNA-LNP vaccine formulation based on the GAS vaccine, Combo#5. Combo#5...

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Share to Antimicrobial Resistance in Staphylococcus
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PMID: 40592845
DOI: 10.1038/s41467-025-60580-0

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