Article

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

2022-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation c...

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Literature Corpus work: cacbf9de-ecd7-555d-bdb7-a772fae1866b
DOI: 10.1101/2022.03.16.484616

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