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Article

Differential effect of plakoglobin in restoring the tumor suppressor activities of p53-R273H vs. p53-R175H mutants.

PloS one - 1 Jan 2024

Lo Chu Shiun, Alavi Parnian, Bassey-Archibong Blessing, Jahroudi Nadia, Pasdar Manijeh

Abstract excerpt

The six most common missense mutations in the DNA binding domain of p53 are known as "hot spots" and include two of the most frequently occurring p53 mutations (p53-R175H and p53-R273H). p53 stability and function are regulated by various post-translational modifications such as phosphorylation, acetylation, sumoylation, methylation, and interactions with other proteins including plakoglobin. Previously, using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39361615
DOI: 10.1371/journal.pone.0306705
PMCID: PMC11449273

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