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Article

Pentoxifylline attenuates nonalcoholic fatty liver by inhibiting hepatic macrophage polarization to the M1 phenotype.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Nov 2022

Xu Dongqin, Zhao Wenhao, Feng Yiting, Wen Xiao, Liu Hanxiao, Ping Jie

Abstract excerpt

BACKGROUND: Nonalcoholic fatty liver (NAFL), recognized as one of the most common causes of chronic liver diseases, is increasingly prevalent worldwide. Pentoxifylline, a derivative of theobromine extracted from Theobroma cacao and tea, has been studied for effects on blood viscosity, tissue oxygenation and inflammation. However, its effects on hepatic lipid accumulation and the potential mechanisms remain...

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Identifiers

PMID: 35994850
DOI: 10.1016/j.phymed.2022.154368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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