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Article

Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily

1 Apr 2000

Abstract excerpt

The Siglecs are a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily. We report a molecule showing homology to the six first reported Siglecs, with the closest relationship to Siglec-3(CD33), Siglec-5, and Siglec-6(OBBP-1). The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known to be involved in...

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PMID: 10764831
DOI: 10.1093/glycob/10.4.431

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