Article

Pathogenic desmin variants impair nuclear integrity and drive atrial cardiomyopathy

2026-04-09

Abstract excerpt

<h4>Background</h4> Pathogenic desmin ( DES) variants have been implicated in early-onset atrial disease, yet the mechanisms by which desmin dysfunction alters atrial structure and function remain unclear. Desmin anchors the cytoskeleton to the nuclear envelope (NE) through the linker of nucleoskeleton and cytoskeleton (LINC) complex, suggesting that defects in this network may drive atrial cardiomyopathy. <h4>...

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Literature Corpus work: bd31d725-897c-5be5-a0ff-d484855af395
DOI: 10.64898/2026.04.07.26348559

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