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Article

Modulation of human-to-swine influenza a virus adaptation by the neuraminidase low-affinity calcium-binding pocket.

Communications biology - 1 Oct 2024

Cardenas Matias, Seibert Brittany, Cowan Brianna, Caceres C Joaquin, Gay L Claire, Cargnin Faccin Flavio, Perez Daniel R, Baker Amy L, Anderson Tavis K, Rajao Daniela S

Abstract excerpt

Frequent interspecies transmission of human influenza A viruses (FLUAV) to pigs contrasts with the limited subset that establishes in swine. While hemagglutinin mutations are recognized for their role in cross-species transmission, the contribution of neuraminidase remains understudied. Here, the NA's role in FLUAV adaptation was investigated using a swine-adapted H3N2 reassortant virus with human-derived HA and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39354058
DOI: 10.1038/s42003-024-06928-6
PMCID: PMC11445579

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