Influenza A viruses of swine circulating in the United States during 2009-2014 are susceptible to neuraminidase inhibitors but show lineage-dependent resistance to adamantanes.

doi:10.1016/j.antiviral.2015.02.004

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Article

Influenza A viruses of swine circulating in the United States during 2009-2014 are susceptible to neuraminidase inhibitors but show lineage-dependent resistance to adamantanes.

Antiviral research - 1 May 2015

Baranovich Tatiana, Bahl Justin, Marathe Bindumadhav M, Culhane Marie, Stigger-Rosser Evelyn, Darnell Daniel, Kaplan Bryan S, Lowe James F, Webby Richard J, Govorkova Elena A

Abstract excerpt

Antiviral drug susceptibility is one of the evaluation criteria of pandemic potential posed by an influenza virus. Influenza A viruses of swine (IAV-S) can play an important role in generating novel variants, yet limited information is available on the drug resistance profiles of IAV-S circulating in the U.S. Phenotypic analysis of the IAV-S isolated in the U.S. (2009-2011) (n=105) revealed normal inhibition by...

Topics

Acids, Carbocyclic
Adamantane
Amino Acid Substitution
Animals
Antiviral Agents
Base Sequence
Cyclopentanes
Dogs
Drug Resistance, Viral
Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Guanidines

Influenza A Virus, H1N1 Subtype

Influenza A Virus, H1N2 Subtype

Influenza A Virus, H3N2 Subtype

Influenza A virus

Madin Darby Canine Kidney Cells

Mutation, Missense

Source

Open in PubMed Open full text

Identifiers

PMID: 25701593
DOI: 10.1016/j.antiviral.2015.02.004
PMCID: PMC4388807

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