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GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

14 Jan 2025

Abstract excerpt

The Eurasian avian-like (EA) H1N1 swine influenza virus (SIV) possesses the capacity to instigate the next influenza pandemic, owing to its heightened affinity for the human-type α-2,6 sialic acid (SA) receptor. Nevertheless, the molecular mechanisms underlying the switch in receptor binding preferences of EA H1N1 SIV remain elusive. In this study, we conduct a comprehensive genome-wide CRISPR/Cas9 knockout...

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PMID: 39809757
DOI: 10.1038/s41467-025-55903-0

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