Article
Residue 41 of the Eurasian avian-like swine influenza a virus matrix protein modulates virion filament length and efficiency of contact transmission.
Journal of virology - 1 Jul 2014
Campbell Patricia J, Kyriakis Constantinos S, Marshall Nicolle, Suppiah Suganthi, Seladi-Schulman Jill, Danzy Shamika, Lowen Anice C, Steel John
Abstract excerpt
UNLABELLED: Position 41 of the influenza A virus matrix protein encodes a highly conserved alanine in human and avian lineages. Nonetheless, strains of the Eurasian avian-like swine (Easw) lineage contain a change at this position: position 41 of A/swine/Spain/53207/04 (H1N1) (SPN04) encodes a proline. To assess the impact of this naturally occurring polymorphism on viral fitness, we utilized reverse genetics to...
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