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Lactylation-related gene signatures identify glioma molecular subtypes with prognostic, immunological, and therapeutic implications

16 Jul 2025

Abstract excerpt

Introduction: Lactic acid is a by-product of energy metabolism and a signaling molecule that influences tumor progression by regulating immune cell function, angiogenesis, and epigenetic modifications. Methods: This study analyzed data from the TCGA database on gliomas to systematically elucidate the expression patterns, prognostic value, and functional regulatory networks of lactylation-related genes. Results:...

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PMID: 40740857
DOI: 10.3389/fonc.2025.1613423

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