Article
The genetic landscape of basal ganglia and implications for common brain disorders.
Nature communications - 1 Oct 2024
Bahrami Shahram, Nordengen Kaja, Rokicki Jaroslav, Shadrin Alexey A, Rahman Zillur, Smeland Olav B, Jaholkowski Piotr P, Parker Nadine, Parekh Pravesh, O'Connell Kevin S, Elvsåshagen Torbjørn, Toft Mathias, Djurovic Srdjan, Dale Anders M, Westlye Lars T, Kaufmann Tobias, Andreassen Ole A
Abstract excerpt
The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans. Our multivariate GWAS...
Topics
- Humans
- Basal Ganglia
- Genome-Wide Association Study
- Parkinson Disease
- Female
- Male
- Middle Aged
- Genetic Predisposition to Disease
- Aged
- Polymorphism, Single Nucleotide