Article

The genetic architecture of human brainstem structures and their involvement in common brain disorders

2019-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Brainstem regions support critical bodily functions, yet their genetic architectures and involvement in brain disorders remain understudied. Here, we examined volumes of brainstem structures using magnetic resonance imaging in 43,353 individuals. In 27,034 genotyped healthy participants, we identified 16 genetic loci associated with whole brainstem volume and 10, 23, 3, and 9 loci associated wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4f33a80-2adf-5c86-af67-a10c3b6a2b53
DOI: 10.1101/811711

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The genetic architecture of human brainstem structures and their involvement in common brain disordersDOI 10.1101/811711Read

The genetic architecture of human brainstem structures and their involvement in common brain disordersSemantic proximity Read

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals WorldwideSemantic proximity Read

Common genetic variants influence human subcortical brain structures.Semantic proximity Read

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.Semantic proximity Read

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestriesSemantic proximity Read

The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathologySemantic proximity Read

Subcortical brain alterations in carriers of genomic copy number variantsSemantic proximity Read

The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.Semantic proximity Read

Unveiling the Genetic Landscape of Basal Ganglia: Implications for Common Brain DisordersSemantic proximity Read

Genome-wide association study of cerebellar volumeSemantic proximity Read

Mapping Focal and Generalized Effects of Common Genetic Variants on Human Brain StructureSemantic proximity Read

A pattern of continuity from health to disease in neuropsychiatric genetic risk affecting brain morphologySemantic proximity Read