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The genetic architecture of human brainstem structures and their involvement in common brain disorders

11 Aug 2020

Abstract excerpt

Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432...

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PMID: 32782260
DOI: 10.1038/s41467-020-17376-1

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