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Renal fibroblasts are involved in fibrogenic changes in kidney fibrosis associated with dysfunctional telomeres

1 Oct 2024

Abstract excerpt

Tubulointerstitial fibrosis associated with chronic kidney disease (CKD) represents a global health care problem. We previously reported that short and dysfunctional telomeres lead to interstitial renal fibrosis; however, the cell-of-origin of kidney fibrosis associated with telomere dysfunction is currently unknown. We induced telomere dysfunction by deleting the Trf1 gene encoding a telomere-binding factor...

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Share to Renal and related cancers
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PMID: 39349834
DOI: 10.1038/s12276-024-01318-8

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