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Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

5 Nov 2008

Abstract excerpt

Fibroblasts are key mediators of fibrosis in the kidney and other organs, but their origin during fibrosis is still not completely clear. Activated fibroblasts likely arise from resident quiescent fibroblasts via epithelial-to-mesenchymal transition and from the bone marrow. Here, we demonstrate that endothelial cells also contribute to the emergence of fibroblasts during kidney fibrosis via the process of...

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Share to Chronic Kidney Disease and Diabetes
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PMID: 18987304
DOI: 10.1681/asn.2008050513

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