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Article

Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2010

Conover Cheryl A, Mason Megan A, Bale Laurie K, Harrington Sean C, Nyegaard Mette, Oxvig Claus, Overgaard Michael T

Abstract excerpt

Pregnancy-associated plasma protein-A (PAPP-A) increases local IGF-I bioavailability through cleavage of inhibitory IGF binding protein (IGFBP)-4 in a variety of systems, including the cardiovascular system. To test the hypothesis that expression of PAPP-A promotes the development of atherosclerotic lesions, we generated transgenic mice that express human PAPP-A in arterial smooth muscle. Four founder lines were...

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Identifiers

PMID: 20472761
DOI: 10.1152/ajpheart.00904.2009
PMCID: PMC2930380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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