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Article

Androgen Receptor Splice Variants Contribute to the Upregulation of DNA Repair in Prostate Cancer

13 Sept 2022

Abstract excerpt

BACKGROUND: Canonical androgen receptor (AR) signaling regulates a network of DNA repair genes in prostate cancer (PCA). Experimental and clinical evidence indicates that androgen deprivation not only suppresses DNA repair activity but is often synthetically lethal in combination with PARP inhibition. The present study aimed to elucidate the impact of AR splice variants (AR-Vs), occurring in advanced or...

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PMID: 36139600
DOI: 10.3390/cancers14184441

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