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Article

Second-order group knockoffs with applications to genome-wide association studies.

Bioinformatics (Oxford, England) - 1 Oct 2024

Chu Benjamin B, Gu Jiaqi, Chen Zhaomeng, Morrison Tim, Candès Emmanuel, He Zihuai, Sabatti Chiara

Abstract excerpt

MOTIVATION: Conditional testing via the knockoff framework allows one to identify-among a large number of possible explanatory variables-those that carry unique information about an outcome of interest and also provides a false discovery rate guarantee on the selection. This approach is particularly well suited to the analysis of genome-wide association studies (GWAS), which have the goal of identifying genetic...

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PMID: 39340798
DOI: 10.1093/bioinformatics/btae580
PMCID: PMC11639161

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