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Article

Association screening of common and rare genetic variants by penalized regression.

Bioinformatics (Oxford, England) - 1 Oct 2010

Zhou Hua, Sehl Mary E, Sinsheimer Janet S, Lange Kenneth

Abstract excerpt

MOTIVATION: This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants. RESULTS: The new strategy is tested on both simulated and real data. Our findings on breast cancer data replicate previous results and shed light on variant effects within genes. AVAILABILITY: Rare variant discovery by group penalized regression is now implemented...

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Identifiers

PMID: 20693321
DOI: 10.1093/bioinformatics/btq448
PMCID: PMC3025646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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