Article
CD4+ Effective Memory T Cell Markers GBP2 and LAG3 Are Risk Factors for PTB and COVID-19 Infection: A Study Integrating Single-Cell Expression Quantitative Trait Locus and Mendelian Randomization Analyses.
International journal of molecular sciences - 16 Sept 2024
Zhu Liangyu, Wu Hanxin, Peng Li, Huang Xun, Yang Rui, Ma Weijie, Zhong Lei, Li Bingxue, Song Jieqin, Luo Suyi, Gao Li, Wu Xinya, Ma Weijiang, Bao Fukai, Liu Aihua
Abstract excerpt
Observational studies indicate that variations in peripheral blood mononuclear cell (PBMC) subsets are associated with an increased risk of pulmonary tuberculosis (PTB) and coronavirus disease 2019 (COVID-19), but causal validation is lacking. Here, we combined single-cell expression quantitative trait locus (sc-eQTL) and two-sample mendelian randomization (MR) analyses to elucidate the causal relationship...
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