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Single-Cell and Mendelian Randomization Analyses Identify Key Genes Common to COVID-19 and Multiple Sclerosis.

Viral immunology - 1 May 2026

Chen Shuping, Ruan Jun, Cheng Sikai, Zheng Huifang, Chang Tianyu, Bao Guichun, Zhu Zijing, Li Xinglin, Zhao Wei, Zheng Kunwen

Abstract excerpt

The pathophysiology of multiple sclerosis (MS) bears notable similarities to the dysregulated inflammatory response occurring during coronavirus disease 2019 (COVID-19) infection. B cells play a pivotal role among immune cells in the pathogenesis of both these diseases. Consequently, clarifying the molecular mechanism underlying B cell function in COVID-19 and MS is of great significance for formulating more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41841545
DOI: 10.1177/08828245261426986

Genes

IKZF3
ANAPC5
DR1
RUVBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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