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Merkel Cell Polyomavirus Large T Antigen Has Growth-Promoting and Inhibitory Activities

21 Mar 2013

Abstract excerpt

Merkel cell carcinoma (MCC) is a rare and aggressive form of skin cancer. In at least 80% of all MCC, Merkel cell polyomavirus (MCPyV) DNA has undergone clonal integration into the host cell genome, and most tumors express the MCPyV large and small T antigens. In all cases of MCC reported to date, the integrated MCPyV genome has undergone mutations in the large T antigen. These mutations result in expression of a...

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PMID: 23514892
DOI: 10.1128/jvi.00385-13

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