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Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

27 Sept 2024

Abstract excerpt

We describe a process for rapid antibody affinity optimization by repertoire mining to identify clones across B cell clonal lineages based on convergent immune responses where antigen-specific clones with the same heavy (VH) and light chain germline segment pairs, or parallel lineages, bind a single epitope on the antigen. We use this convergence framework to mine unique and distinct VH lineages from rat...

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PMID: 39333507
DOI: 10.1038/s41467-024-52442-y

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