Article
Tubulin interaction at tubulin-binding sequence 1 (TBS1) is required for proper surface expression and TRPV1 channel activity.
Life sciences - 15 Nov 2024
Mohanta Sushama, Saha Somdatta, Das Nilesh Kumar, Swain Nirlipta, Kumar Satish, Goswami Chandan
Abstract excerpt
TRPV1, a polymodal and nonselective cation channel has unique gating mechanisms which is regulated by supramolecular complexes at the plasma membrane formed with membrane proteins, lipids and kinase pathways. Crosstalk between microtubule cytoskeleton with TRPV1 at various level has been established. Previously we demonstrated that the positively-charged residues present at specific tubulin-binding stretch...
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