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Article

Key residues on microtubule responsible for activation of kinesin ATPase.

The EMBO journal - 7 Apr 2010

Uchimura Seiichi, Oguchi Yusuke, Hachikubo You, Ishiwata Shin'ichi, Muto Etsuko

Abstract excerpt

Microtubule (MT) binding accelerates the rate of ATP hydrolysis in kinesin. To understand the underlying mechanism, using charged-to-alanine mutational analysis, we identified two independent sites in tubulin, which are critical for kinesin motility, namely, a cluster of negatively charged residues spanning the helix 11-12 (H11-12) loop and H12 of alpha-tubulin, and the negatively charged residues in H12 of...

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Identifiers

PMID: 20224548
DOI: 10.1038/emboj.2010.25
PMCID: PMC2857467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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