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Article

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response.

Life science alliance - 1 Nov 2021

Beijer Danique, Agnew Thomas, Rack Johannes Gregor Matthias, Prokhorova Evgeniia, Deconinck Tine, Ceulemans Berten, Peric Stojan, Milic Rasic Vedrana, De Jonghe Peter, Ahel Ivan, Baets Jonathan

Abstract excerpt

ADP ribosylation is a reversible posttranslational modification mediated by poly(ADP-ribose)transferases (e.g., PARP1) and (ADP-ribosyl)hydrolases (e.g., ARH3 and PARG), ensuring synthesis and removal of mono-ADP-ribose or poly-ADP-ribose chains on protein substrates. Dysregulation of ADP ribosylation signaling has been associated with several neurodegenerative diseases, including Parkinson's disease, amyotrophic...

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Identifiers

PMID: 34479984
DOI: 10.26508/lsa.202101057
PMCID: PMC8424258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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