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Article

Expanding the Molecular Spectrum of Carcinoma Ex Pleomorphic Adenoma: An Analysis of 84 Cases With a Novel HMGA2::LINC02389 Fusion.

The American journal of surgical pathology - 1 Dec 2024

de Lima-Souza Reydson Alcides, Altemani Albina, Michal Michal, Mariano Fernanda Viviane, Leivo Ilmo, Skálová Alena

Abstract excerpt

Carcinoma ex pleomorphic adenoma (CXPA) is an aggressive epithelial and/or myoepithelial neoplasm that arises in association with a pleomorphic adenoma (PA). Its etiopathogenesis remains poorly understood, but it is believed that the development of this tumor is due to the accumulation of genetic, protein, metabolic, and epigenetic alterations in a PA. A retrospective review of the Salivary Gland Tumor Registry...

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Source

Identifiers

PMID: 39324957
DOI: 10.1097/PAS.0000000000002307

Genes

HMGA2
PLAG1
EWSR1
CTNNB1
ERBB2
FGFR1
HRAS
LIFR
MDM2
MYB
PTEN
TP53

Provenance

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Related research

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Research trail→

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Expanding the Molecular Spectrum of Carcinoma Ex Pleomorphic AdenomaPMID 39324957Read ↗

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Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations.Semantic proximity Read ↗

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Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary GlandsSemantic proximity Read ↗

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