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Article

Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands.

The American journal of surgical pathology - 1 Jun 2025

Klubíčková Natálie, Loghides Frederica, van den Hout Mari F C M, Costes-Martineau Valérie, Ferrara Gerardo, Rito Miguel, Hájková Veronika, Grossmann Petr, Šteiner Petr, Kovářová Inka, Michal Michal, Leivo Ilmo, Skálová Alena

Abstract excerpt

Canalicular tumors of the salivary glands have recently emerged as an entity characterized by distinct morphology and recurrent HMGA2 gene rearrangement. In this study, we analyzed 40 cases intending to elucidate their features further. The monophasic or biphasic tumors exhibited a growth pattern of interconnected anastomosing trabeculae and canaliculi, accompanied by a classical pleomorphic adenoma in one-third...

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Source

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Identifiers

PMID: 40033554
DOI: 10.1097/PAS.0000000000002377
PMCID: PMC12068546

Genes

HMGA2
MSRB3
AR
ARID2
FHIT
HMGA1
IFNG
SOX10
WIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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