Article
Insights into the molecular alterations of PLAG1 and HMGA2 associated with malignant phenotype acquisition in pleomorphic adenoma.
Critical reviews in oncology/hematology - 1 Dec 2024
de Lima-Souza Reydson Alcides, Vieira Gustavo de Souza, Kimura Talita de Carvalho, Scarini João Figueira, Lavareze Luccas, Maciel Tayná Figueiredo, Gonçalves Moisés Willian Aparecido, Egal Erika Said Abu, Altemani Albina, Mariano Fernanda Viviane
Abstract excerpt
Pleomorphic adenoma (PA) is the most common neoplasm of the salivary gland, presenting with a variety of histological features. In some cases, PA can undergo malignant transformation to carcinoma ex pleomorphic adenoma (CXPA). The transition from PA to CXPA is associated with complex molecular alterations, particularly involving the pleomorphic adenoma gene 1 (PLAG1) and high mobility group protein gene (HMGA2)....
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