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Article

Dual gain of HER2 and EGFR gene copy numbers impacts the prognosis of carcinoma ex pleomorphic adenoma.

Human pathology - 1 Nov 2015

Nishijima Toshimitsu, Yamamoto Hidetaka, Nakano Takafumi, Nakashima Torahiko, Taguchi Ken-ichi, Masuda Muneyuki, Motoshita Jun-ichi, Komune Shizuo, Oda Yoshinao

Abstract excerpt

We investigated the potential roles of HER2 and EGFR and evaluated their prognostic significance in carcinoma ex pleomorphic adenoma (CXPA). We analyzed HER2 and EGFR overexpression status using immunohistochemistry (IHC) and gene copy number gain by chromogenic in situ hybridization (CISH) in 50 cases of CXPA (40 ductal-type and 10 myoepithelial-type CXPAs). Salivary duct carcinoma was the most common histologic...

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Source

Identifiers

PMID: 26345124
DOI: 10.1016/j.humpath.2015.07.014

Genes

EGFR
CISH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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