Article
Epithelial-Myoepithelial Carcinoma: Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases.
The American journal of surgical pathology - 1 Jan 2018
El Hallani Soufiane, Udager Aaron M, Bell Diana, Fonseca Isabel, Thompson Lester D R, Assaad Adel, Agaimy Abbas, Luvison Alyssa M, Miller Caitlyn, Seethala Raja R, Chiosea Simion
Abstract excerpt
We hypothesized that there is a relationship between the preexisting pleomorphic adenoma [PA]), histologic grade of epithelial-myoepithelial carcinomas (EMCAs), and genetic alterations. EMCAs (n=39) were analyzed for morphologic and molecular evidence of preexisting PA (PLAG1, HMGA2 status by fluorescence in situ hybridization, FISH, and FGFR1-PLAG1 fusion by next-generation sequencing, NGS). Twenty-three EMCAs...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.