Article
Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma.
World journal of surgical oncology - 13 Jun 2020
Eichenauer Till, Shadanpour Navid, Kluth Martina, Göbel Cosima, Weidemann Sören, Fraune Christoph, Büscheck Franziska, Hube-Magg Claudia, Möller-Koop Christina, Dahlem Roland, Fisch Margit, Rink Michael, Riechardt Silke, Burandt Eike, Bernreuther Christian, Minner Sarah, Simon Ronald, Sauter Guido, Wilczak Waldemar, Clauditz Till
Abstract excerpt
BACKGROUND: Deletions of 17p13 recurrently occur in renal cell carcinoma (RCC) but their prognostic role seems to be uncertain. METHODS: To determine prevalence, relationship with tumor phenotype, and patient prognosis, a tissue microarray containing samples from 1809 RCCs was evaluated using dual labeling fluorescence in situ hybridization (FISH) with 17p13 and chromosome 17 centromere probes. RESULTS: A 17p13...
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