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Article

Prevalence of pancreaticobiliary cancers in Irish families with pathogenic BRCA1 and BRCA2 variants.

Familial cancer - 1 Apr 2021

Power Robert, Leavy Cristin, Nolan Carmel, White Niamh, Clarke Roisin, Cadoo Karen A, Gallagher David James, Lowery Maeve Aine

Abstract excerpt

Pathogenic variants (PVs) in the BRCA1 and BRCA2 genes are associated with an increased lifetime risk of pancreatic ductal adenocarcinoma (PDAC), and more recently have been associated with increased risk of biliary tract cancers (BTC). This study assessed the prevalence, age and gender distribution of PDAC/BTC cases in families known to carry a BRCA1/2 PV compared to those of the Irish population. A review of...

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Identifiers

PMID: 32918181
DOI: 10.1007/s10689-020-00205-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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