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Article

Pancreatic agenesis and altered m6A methylation in the pancreas of PDX1-mutant cynomolgus macaques.

Zoological research - 18 Nov 2024

Zhang Wen-Hui, Zhuang Jiong-Han, Guo Yun-Yi, Chen Xue-Ying, Li Ya-Qing, Xu Jie-Qiu, Zhang An-Ran, Chen Bao-Yi, Meng Wei, Zhu Yan-Hua, Huang Jun-Jiu, Guo Yong-Long, Yang Shi-Hua

Abstract excerpt

As an essential transcriptional activator, PDX1 plays a crucial role in pancreatic development and β-cell function. Mutations in the PDX1 gene may lead to type 4 maturity-onset diabetes of the young (MODY4) and neonatal diabetes mellitus. However, the precise mechanisms underlying MODY4 remain elusive due to the paucity of clinical samples and pronounced differences in pancreatic architecture and genomic...

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Identifiers

PMID: 39318126
DOI: 10.24272/j.issn.2095-8137.2024.044
PMCID: PMC11668947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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