Article

Inhibition of miR-199b-5p reduces pathological alterations in Osteoarthritis by potentially targeting <i>Fzd6</i> and <i>Gcnt2</i>

2023-10-03

Abstract excerpt

Osteoarthritis (OA) is a degenerative disease with a high prevalence in the elderly population, but our understanding of its mechanisms remains incomplete. Analysis of serum exosomal small RNA sequencing data from clinical patients and gene expression data from OA patient serum and cartilage obtained from the GEO database revealed a common dysregulated miRNA, miRNA-199b-5p. In vitro cell experiments demonstrated t...

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Literature Corpus work: de94786c-68a4-5999-9acd-c8f52da37e2c
DOI: 10.1101/2023.10.03.560693

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