Article
Comparative analysis of the tumor immune-microenvironment of primary and brain metastases of non-small-cell lung cancer reveals organ-specific and EGFR mutation-dependent unique immune landscape.
Cancer immunology, immunotherapy : CII - 1 Jul 2021
Song Seung Geun, Kim Sehui, Koh Jaemoon, Yim Jeemin, Han Bogyeong, Kim Young A, Jeon Yoon Kyung, Chung Doo Hyun
Abstract excerpt
BACKGROUND: To evaluate the characteristics of the tumor immune-microenvironment in brain metastases of non-small-cell lung cancer (NSCLC), we investigated the immunophenotype of primary NSCLC and its brain metastasis. METHODS: Expression profiling of 770 immune-related genes in 28 tissues from primary and brain metastases of NSCLC was performed using the NanoString nCounter PanCancer Immune Profiling Panel. The...
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