Article
Epstein-Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements.
Nature - 1 Jan 2000
Katamine S, Otsu M, Tada K, Tsuchiya S, Sato T, Ishida N, Honjo T, Ono Y
Abstract excerpt
The very early stages of the human B-cell differentiation pathway are poorly understood, primarily because of the lack of appropriate permanent cell lines. Epstein-Barr virus (EBV) is a putative human oncogenic virus which transforms human B cells in vitro into continuously proliferating cells. I...
Topics
- Animals
- Antigens, Surface
- B-Lymphocytes
- Callitrichinae
- Cell Differentiation
- Cell Line
- Cell Transformation, Neoplastic
- Fetus
- Genes
- Herpesvirus 4, Human
- Immunoglobulin Heavy Chains
- Immunoglobulins
- Phenotype
- Receptors, Immunologic