Article
Epstein-Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements.
Nature - 1 Jan 2000
Katamine S, Otsu M, Tada K, Tsuchiya S, Sato T, Ishida N, Honjo T, Ono Y
Abstract excerpt
The very early stages of the human B-cell differentiation pathway are poorly understood, primarily because of the lack of appropriate permanent cell lines. Epstein-Barr virus (EBV) is a putative human oncogenic virus which transforms human B cells in vitro into continuously proliferating cells. It has been believed that EBV transforms mature B cells, but recently, transformation of immature pre-B-cell lines has...
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