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Article

Distinct mutation features and its clinical significance in myelodysplastic syndromes with normal karyotype.

Annals of hematology - 1 Nov 2024

Huang Nanfang, Chang Chunkang, Wu Lingyun, He Qi, Zhang Zheng, Li Xiao, Xu Feng

Abstract excerpt

Myelodysplastic syndromes (MDS) is a highly heterogeneous myeloid neoplastic disease, which needs personalized evaluation and therapy. To analyze the features and significance of gene mutations for MDS patients with normal karyotype (NK) at diagnosis, targeted sequencing was conducted on 616 MDS patients with NK, alongside 457 MDS cases with abnormal karyotype (AK). The results showed that the incidence of...

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PMID: 39302466
DOI: 10.1007/s00277-024-06005-2

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