Article
The utility of a myeloid mutation panel for the diagnosis of myelodysplastic syndrome and myelodysplastic/myeloproliferative neoplasm.
International journal of laboratory hematology - 1 Dec 2021
Ibrar Warda, Zhang Weiwei, Cox Jesse Lee, Cushman-Vokoun Allison, Fu Kai, Greiner Timothy C, Yuan Ji
Abstract excerpt
INTRODUCTION: The diagnosis of myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) is based on morphology and cytogenetics/FISH findings per 2017 WHO classification. With rare exceptions, somatic mutations have not been incorporated as the diagnostic criteria. METHODS: We analyzed the utility of mutational analysis with a targeted 54-gene or 40-gene next-generation...
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