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Article

BRAF mutations and the association of V600E with CD133 and CDX2 expression in a Pakistani colorectal carcinoma cohort.

BMC cancer - 19 Sept 2024

Hassan Sobia, Mirza Talat, Khatoon Ambrina, Bukhari Uzma, Shaikh Fouzia, Karim Asad

Abstract excerpt

BACKGROUND: Despite a high incidence of colorectal carcinoma, data regarding genetic aberrations in colorectal carcinoma (CRC) patients in Pakistan is scarce. This study aimed to determine the frequency of BRAFV600E mutations in colorectal carcinoma tissue in the Pakistani population and to associate BRAFV600E expression with CD133, a marker of colorectal stem cells, and CDX2 marker of differentiation. METHODS:...

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Identifiers

PMID: 39300378
DOI: 10.1186/s12885-024-12925-z
PMCID: PMC11411998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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