Article

Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids

2023-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Microvillus Inclusion Disease (MVID), caused by loss-of-function mutations in the motor protein Myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea, malabsorption, and acid-base instability, requiring intensive parenteral support for nutritional and fluid management. Human patient-derived enteroids represent a model for investigation of monogenic epithelial disorders but a...

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Literature Corpus work: ab82fa6f-c703-5be8-b3c2-3ff91ce8da7e
DOI: 10.1101/2023.01.28.526036

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