Article
Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-Lined Inclusions and Alterations in Sodium Transporters.
Gastroenterology - 1 Jun 2020
Engevik Amy C, Coutts Alexander W, Kaji Izumi, Rodriguez Paula, Ongaratto Felipe, Saqui-Salces Milena, Medida Ramya Lekha, Meyer Anne R, Kolobova Elena, Engevik Melinda A, Williams Janice A, Shub Mitchell D, Carlson Daniel F, Melkamu Tamene, Goldenring James R
Abstract excerpt
BACKGROUND & AIMS: Microvillus inclusion disease (MVID) is caused by inactivating mutations in the myosin VB gene (MYO5B). MVID is a complex disorder characterized by chronic, watery, life-threatening diarrhea that usually begins in the first hours to days of life. We developed a large animal model of MVID to better understand its pathophysiology. METHODS: Pigs were cloned by transfer of chromatin from swine...
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