Article
IDH1 mutation is detectable in plasma cell-free DNA and is associated with survival outcome in glioma patients.
BMC cancer - 3 Jan 2024
Crucitta Stefania, Pasqualetti Francesco, Gonnelli Alessandra, Ruglioni Martina, Luculli Giovanna Irene, Cantarella Martina, Ortenzi Valerio, Scatena Cristian, Paiar Fabiola, Naccarato Antonio Giuseppe, Danesi Romano, Del Re Marzia
Abstract excerpt
BACKGROUND: Circulating cell-free DNA (cfDNA, liquid biopsy) is a powerful tool to detect molecular alterations. However, depending on tumor characteristics, biology and anatomic localization, cfDNA detection and analysis may be challenging. Gliomas are enclosed into an anatomic sanctuary, which obstacles the release of cfDNA into the peripheral blood. Therefore, the advantages of using liquid biopsy for brain...
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