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Article

Evolution of pH-sensitive transcription termination in Escherichia coli during adaptation to repeated long-term starvation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2024

Worthan Sarah B, McCarthy Robert D P, Delaleau Mildred, Stikeleather Ryan, Bratton Benjamin P, Boudvillain Marc, Behringer Megan G

Abstract excerpt

Fluctuating environments that consist of regular cycles of co-occurring stress are a common challenge faced by cellular populations. For a population to thrive in constantly changing conditions, an ability to coordinate a rapid cellular response is essential. Here, we identify a mutation conferring an arginine-to-histidine (Arg to His) substitution in the transcription terminator Rho. The rho R109H mutation...

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Share to Adaptation, Physiological
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Evolution, Molecular

Share to Gene Expression Regulation, Bacterial

Share to Hydrogen-Ion Concentration

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Source

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Identifiers

PMID: 39298488
DOI: 10.1073/pnas.2405546121
PMCID: PMC11441560

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